TAB3 Antibody

CAT: 0223-3391-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-3391-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
TAB3 Antibody: TAB3 functions in the NF-kappaB signal transduction pathway. It and the similar and functionally redundant protein TAB2, form a ternary complex with the protein kinase TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. Recent experiments have shown that TAB2 and the related protein TAB3 constitutitvely interact with the autophagy mediator Beclin-1; upon induction of autophagy, these proteins dissociate from Beclin-1 and bind TAK1. Overexpression of TAB2 and TAB3 inhibit autophagy, while their depletion triggers it, suggesting that TAB2 and TAB3 act as a control point for autophagy.
NCBI Gene ID
257397
Swiss Prot
Q8N5C8
Accession Number
NP_690000
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Autophagy
Purification
TAB3 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 10-401 - Human Kidney Tissue Slide
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Mouse: (92%)
Buffer
TAB3 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
TAB3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
TAB3 antibody is human specific. TAB3 antibody is predicted not to cross-react with other TAB proteins.
Symbol
TAB3
NCBI Official Name
TGF-beta activated kinase 1/MAP3K7 binding protein 3
NCBI Organism
Homo sapiens
Background Reference 01
Cheung PC, Nebreda AR, and Cohen P. TAB3, a new binding partner of the protein kinase TAK1. Biochem. J. 2004; 378:27-34.
Background Reference 02
Besse A, Lamothe B, Campos AD, et al. TAK1-dependent signaling requires functional interaction with TAB2/TAB3. J. Biol. Chem. 2007; 282:3918-28.
Background Reference 03
Criollo A, Niso-Santano M, Malik SA, et al. Inhibition of autophagy by TAB2 and TAB3. EMBO J. 2011; 30:4908-20.
Other Product Names
TAB3 Antibody: NAP1, MAP3K7IP3, TGF-beta-activated kinase 1 and MAP3K7-binding protein 3, Mitogen-activated protein kinase kinase kinase 7-interacting protein 3, TAB-3
Tested Applications
ELISA, IHC-P
Protein ID
98991767
Physical Properties
Liquid

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