TAB3 Antibody

• Background:

  TAB3, a TAB2-like protein, is a mediator of TAK1 activation in IL-1 and TNF signaling. IL-1 and TNF are cytokines involved in the inflammation process, initiating signaling cascades leading to the activation of NF-kB and mitogen-activated protein kinases (MAPKs) . TAB3 functions as an adapter, linking TAK1 and TRAF6 or TRAF2. This kinase complex phosphorylates IkB, which keeps NF-kB inactive and sequestered in the cytoplasm. Phosphorylation leads to IkB degradation, activating NF-kB, which translocates to the nucleus, binds to DNA response elements and can begin multiple signaling cascades.

• NCBI Gene ID:

  257397

• Swiss Prot:

  Q8N5C8

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  A recombinant protein fragment from the N-terminal region of human TAB3 was used as the immunogen for this antibody.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Autophagy

• Purification:

  Protein A purified antibody

• Concentration:

  0.5 mg/mL

• Buffer:

  PBS with 0.1 mg/ml BSA and 0.05% sodium azide

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Aliquot and Store at -20˚ C. Avoid freez-thaw cycles.

• Fragment:

  IgG

• Symbol:

  TAB3

• NCBI Official Name:

  TGF-beta activated kinase 1/MAP3K7 binding protein 3

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  TAB3 Antibody: NAP1, MAP3K7IP3, TGF-beta-activated kinase 1 and MAP3K7-binding protein 3, Mitogen-activated protein kinase kinase kinase 7-interacting protein 3, TAB-3

• Tested Applications:

  WB

• Physical Properties:

  Liquid