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TAB1 Antibody

CAT: 0223-3387-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-3387-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
TAB1 Antibody: TAB1 was identified as a regulator of the MAP kinase kinase kinase TAK1/MAP3K7, which is known to mediate various intracellular signaling pathways, such as those induced by TGF-beta and members of the Toll-IL-1R (TIR) superfamily, thus acting as an intermediate in both proliferative and innate and adaptive immune responses. This protein, together with either TAB2 or TAB3, activates TAK1 kinase in response to upstream signals. It has been shown that the C-terminal portion of TAB1 is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF-beta, demonstrating how this protein can function as a mediator between TGF-beta receptors and TAK1.
NCBI Gene ID
10454
Swiss Prot
Q15750
Accession Number
NP_006107
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Innate Immunity
Purification
TAB1 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1212 - 3T3 Cell Lysate
Concentration
1 mg/mL
Buffer
TAB1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
TAB1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
TAB1
Positive Control 2
Cat. No. 1204 - K562 Cell Lysate
Positive Control 3
Cat. No. 17-004 - K-562 Cell Slide
Positive Control 4
Cat. No. 17-201 - 3T3/BALB Cell Slide
NCBI Official Name
TGF-beta activated kinase 1 (MAP3K7) binding protein 1
NCBI Organism
Homo sapiens
Background Reference 01
Shibuya H, Yamaguchi K, Shirakabe K, et al. TAB1: an activator of the TAK1 MAPKKK in TGF-β signal transduction. Science 1996; 272:1179-82.
Background Reference 02
Irie T, Muta T, and Takeshige K. TAK1 mediates an activation signal from toll-like receptor (s) to nuclear factor-κ B in lipopolysaccharide-stimulated macrophages. FEBS Lett. 2000; 467:160-4.
Background Reference 03
Akira S and Takeda K. Toll-like receptor Signalling. Nat. Rev. Immunol. 2004; 4:499-511.
Background Reference 04
Jiang Z, Ninomiya-Tsuji J, Qian Y, et al. Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol. Mol. Cell Biol. 2002; 22:7158-67.
Other Product Names
TAB1 Antibody: 3'-Tab1, MAP3K7IP1, TGF-beta-activated kinase 1 and MAP3K7-binding protein 1, Mitogen-activated protein kinase kinase kinase 7-interacting protein 1, TAK1-binding protein 1
Tested Applications
ELISA, WB, ICC, IF
Protein ID
5174703
Physical Properties
Liquid

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