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NAIP Antibody

CAT: 0223-3315-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-3315-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
NAIP Antibody: Neuronal apoptosis inhibitor protein (NAIP) was the first human inhibitor of apoptosis protein (IAP) identified and was discovered by its association with the neurodegenerative disorder spinal muscular atrophy. Members of the IAP family contain one to three copies of an approximately 70 amino acid motif termed baculovirus IAP repeat (BIR) ; these BIRs promote protein-protein interactions with various caspases such as caspase-3, -7, and -9 as well as members of the TRAF family of signal molecules. Unlike other IAPs however, NAIP requires ATP to bind caspase-9 and is not inhibited by the IAP-inhibiting molecule Smac/DIABLO, suggesting that NAIP is unique among the IAPs in its regulation of its activity. Finally, although only one human NAIP protein has been identified, other shorter NAIP mRNA transcripts have been reported.
NCBI Gene ID
4671
Swiss Prot
Q13075
Accession Number
AAC52047
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Cancer
Purification
NAIP Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1315 - Human Tonsil Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Mouse: (92%)
Buffer
NAIP Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
NAIP antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
Minor, lower molecular weight bands may represent alternately spliced forms.
Symbol
NAIP
Positive Control 2
Cat. No. 1203 - A549 Cell Lysate
Positive Control 3
Cat. No. 17-003 - A549 Cell Slide
NCBI Official Name
NLR family, apoptosis inhibitory protein
NCBI Organism
Homo sapiens
Background Reference 01
Roy N, Mahadevan MS, McLean M, et al. The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy. Cell 1995; 80:167-78.
Background Reference 02
Liston P, Fong WG, Korneluk RG. The inhibitors of apoptosis: there is more to life than Bcl2. Oncogene 2003; 22:8568-80.
Background Reference 03
Verhagen AM, Coulson EJ, and Vaux DL. Inhibitor of apoptosis proteins and their relatives: IAPs and other BIRPs. Genome Biol. 2001; 2:reviews3009.1-reviews3009.10.
Background Reference 04
Davoodi J, Lin L, Kelly J, et al. Neuronal apoptosis-inhibitory protein does not interact with Smac and requires ATP to bind caspase-9. J. Biol. Chem. 2004; 279:40622-8.
Other Product Names
NAIP Antibody: BIRC1, NLRB1, psiNAIP, BIRC1, Baculoviral IAP repeat-containing protein 1, Neuronal apoptosis inhibitory protein
Tested Applications
ELISA, WB, ICC, IF
Protein ID
1737213
Physical Properties
Liquid

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