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TLR11 Antibody

CAT: 0223-3285-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-3285-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
TLR11 Antibody: Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors. TLR11 is one of three mouse TLRs that lack a human ortholog. It is activated specifically by uropathogenic bacteria, and mice lacking TLR11 showed a much greater susceptability to uropathogenic infections, indicating a potentially important role for TLR11 in preventing infections in the urogenital system.
NCBI Gene ID
239081
Swiss Prot
Q6R5P0
Accession Number
NP_991388
Host
Rabbit
Reactivity
Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Innate Immunity
Purification
TLR11 Antibody is Ion exchange chromatography purified.
Positive Control
Cat. No. 1283 - RAW 264.7 Cell Lysate
Concentration
1 mg/mL
Buffer
TLR11 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
TLR11 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
Tlr11
Positive Control 2
Cat. No. 17-203 - RAW 264.7 Cell Slide
NCBI Official Name
Toll-like receptor 11
NCBI Organism
Mus musculus
Background Reference 01
Vogel SN, Fitzgerald KA, and Fenton MJ. TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression. Mol. Interv. 2003; 3:466-77.
Background Reference 02
Takeda K, Kaisho T, and Akira S. Toll-like receptors. Annu. Rev. Immunol. 2003; 21:335-76.
Background Reference 03
Janeway CA Jr. and Medzhitov R. Innate immune recognition. Annu. Rev. Immunol. 2002; 20:197-216.
Background Reference 04
O'Neill LAJ, Fitzgerald FA, and Bowie AG. The Toll-IL-1 receptor adaptor family grows to five members. Trends in Imm. 2003; 24:286-9.
Other Product Names
TLR11 Antibody: Gm287, Gm287, Toll-like receptor 11
Tested Applications
ELISA, WB, ICC, IF
Protein ID
45429992
Physical Properties
Liquid

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