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TLR1 Antibody

CAT: 0223-3641-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-3641-01Size:0.02 mg
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Background
TLR1 Antibody: Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors so the organism can respond to potential infection. TLR1 is co-expressed with TLR2 on myeloid cells of the innate immune systems in lymphoid tissue such as monocytes and dendritic cells where they form heterodimers that can recognize triacylated lipoproteins.
NCBI Gene ID
7096
Swiss Prot
Q15399
Accession Number
CAG38593
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Innate Immunity
Purification
TLR1 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1224 - Daudi Cell Lysate
Concentration
1 mg/mL
Buffer
TLR1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
TLR1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
TLR1
Positive Control 2
Cat. No. 1208 - THP-1 Cell Lysate
NCBI Official Name
Toll-like receptor 1
NCBI Organism
Homo sapiens
Background Reference 01
Vogel SN, Fitzgerald KA, and Fenton MJ. TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression. Mol. Interv. 2003; 3:466-77.
Background Reference 02
Takeda K, Kaisho T, and Akira S. Toll-like receptors. Annu. Rev. Immunol. 2003; 21:335-76.
Background Reference 03
Janeway CA Jr. and Medzhitov R. Innate immune recognition. Annu. Rev. Immunol. 2002; 20:197-216.
Background Reference 04
O'Neill LAJ, Fitzgerald FA, and Bowie AG. The Toll-IL-1 receptor adaptor family grows to five members. Trends in Imm. 2003; 24:286-9.
Other Product Names
TLR1 Antibody: TIL, CD281, rsc786, TIL. LPRS5, KIAA0012, Toll-like receptor 1, TIL
Tested Applications
ELISA, WB, ICC
Protein ID
49065550
Physical Properties
Liquid

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