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P53AIP1 Antibody

CAT: 0223-2449-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-2449-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
P53AIP1 Antibody: The p53 tumor-suppressor protein can induce apoptosis through transcriptional activation of several genes. One such protein p53AIP was initially identified through direct cloning of p53 binding sequences from human genomic DNA. Its expression is inducible by p53 following p53 phosphorylation on Ser-46, and ectopic expression of p53AIP leads to apoptotic cell death. Both the phosphorylation of p53 and the induction of p53AIP were blocked by inhibiting the expression of p53DINP1 by the introduction of antisense oligonucleotides to p53DINP1, suggesting that the apoptosis associated with p53AIP expression is regulated by p53DINP1. Finally, as adenovirus-mediated introduction of p53AIP has been shown to suppress tumor growth in vivo, it has been suggested that p53AIP gene transfer may become a useful strategy for the treatment of p53-resistant cancers. Three isoforms of p53AIP are known to exist; this antibody will detect all three.
NCBI Gene ID
63970
Swiss Prot
Q9HCN2
Accession Number
BAB16421
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Cancer
Purification
P53AIP1 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1209 - HL60 Cell Lysate
Concentration
1 mg/ml
Buffer
P53AIP1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
P53AIP1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
TP53AIP1
Positive Control 2
Cat. No. 17-009 - HL-60 Cell Slide
NCBI Official Name
Tumor protein p53 regulated apoptosis inducing protein 1
NCBI Organism
Homo sapiens
Background Reference 01
Kern SE, Pietenpol JA, Thiagalingam S, Seymour A, et al. Oncogenic forms of p53 inhibit p53-regulated gene expression. Science1991; 252:1708-11.
Background Reference 02
Oda K, Arakawa H, Tanaka T, et al. p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53. Cell2000; 102:849-52.
Background Reference 03
Okamura S, Arakawa H, Tanaka T, et al. p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis. Mol. Cell2001; 8:85-94.
Background Reference 04
Yoshida K, Monden M, Nakamura Y, et al. Adenovirus-mediated p53AIP1 gene transfer as a new strategy for treatment of p53-resistant tumors. Cancer Sci.2004; 95:91-7.
Other Product Names
P53AIP1 Antibody: P53AIP1, p53-regulated apoptosis-inducing protein 1, p53AIP1
Tested Applications
ELISA, WB, ICC, IF
Protein ID
10798768
Physical Properties
Liquid

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