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TACI Antibody

CAT: 0223-2395-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-2395-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
TACI Antibody: Members in the TNF superfamily regulate immune responses and induce apoptosis. Two novel members in the TNF family were recently identified and designated BAFF/BLyS/TALL-1/THANK/zTNF4 and April/TALL-2, respectively. BAFF was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. April regulates immunological and non-immunological cell growth. Three receptors, BCMA, TACI, and BAFF-R, for BAFF and April were recently identified. TACI, like BCMA, binds BAFF and April. TACI and its ligands regulate humoral immune responses, activate NF-κ B and c-jun N-terminal kinase, and are involved in B cell associated autoimmune diseases.
NCBI Gene ID
23495
Swiss Prot
O14836
Accession Number
NP_036584
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis
Purification
TACI Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1204 - K562 Cell Lysate
Concentration
1 mg/ml
Buffer
TACI Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
TACI antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
TNFRSF13B
Positive Control 2
Cat. No. 1215 - U937 Cell Lysate
Positive Control 3
Cat. No. 17-004 - K-562 Cell Slide
NCBI Official Name
Tumor necrosis factor receptor superfamily, member 13B
NCBI Organism
Homo sapiens
Background Reference 01
Moore PA, Belvedere O, Orr A, et al. BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator. Science 1999;285:260-3
Background Reference 02
Schneider P, MacKay F, Steiner V, et al. BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth. J Exp Med 1999;189:1747-56
Background Reference 03
Shu HB, Hu WH, Johnson H. TALL-1 is a novel member of the TNF family that is down-regulated by mitogens. J Leukoc Biol 1999;65:680-3
Background Reference 04
Mukhopadhyay A, Ni J, Zhai Y, Yu GL, Aggarwal BB. Identification and characterization of a novel cytokine, THANK, a TNF homologue that activates apoptosis, nuclear factor-κ B, and c-Jun NH2-terminal kinase. J Biol Chem 1999 ;274:15978-81
Other Product Names
TACI Antibody: CVID, RYZN, TACI, CD267, CVID2, TNFRSF14B, Tumor necrosis factor receptor superfamily member 13B, Transmembrane activator and CAML interactor
Tested Applications
ELISA, WB, ICC
Protein ID
6912694
Physical Properties
Liquid

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