TACI Recombinant Protein

• Background:

  TACI, a member of the TNF Receptor superfamily, is expressed in the small intestine, spleen, thymus, peripheral blood leukocytes, activated T cells, and resting B cells. TACI binds to both APRIL and BAFF and can stimulate the activation of transcription factors; NF-kappaB, AP-1, and mediates calcineurin dependent activation of NF-AT (nuclear-factor of activated T cells) . TACI also plays a key role in the stimulation of B and T cell function. Soluble TACI inhibits APRIL-stimulated proliferation of primary B-cells by blocking the binding of APRIL to the membrane anchored TACI receptor. Recombinant human TACI is a soluble 160 amino acid polypeptide (17.8 kDa) comprising the TNFR homologous cysteine rich extracellular domain of the TACI protein.

• NCBI Gene ID:

  23495

• Swiss Prot:

  O14836

• Accession Number:

  NP_036584.1

• Type:

  Recombinant Proteins

• Source:

  E. coli

• Field of Research:

  Apoptosis, Immunology

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  The lyophilized TACI recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted TACI is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing TACI recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

• NCBI Official Name:

  Tumor necrosis factor receptor superfamily, member 13B

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  CVID, RYZN, TACI, CD267, CVID2, TNFRSF14B, Tumor necrosis factor receptor superfamily member 13B, Transmembrane activator and CAML interactor

• Species:

  Human

• Protein ID:

  6912694

• Physical Properties:

  Lyophilized