SnoN Antibody

• Background:

  SnoN Antibody: TGF-beta is a ubiquitously expressed cytokine that signals through the Smad protein family to regulate numerous cellular processes such as embryonic development and tumorigenesis. This signaling is negatively regulated by Ski, the mammalian homolog of the transforming protein of an avian retrovirus that induces oncogenic transformation of chicken embryo cells, and the related protein SnoN. Like Ski, SnoN functions by binding to the Smad proteins and preventing their phosphorylation, thereby inhibiting their ability to bind DNA and activate the transcription of downstream genes. SnoN is located primarily in the nucleus in cancer tissues or cells, but in the cytoplasm in normal tissues or primary epithelial cells. There are at least four alternately spliced isoforms of SnoN; SnoN antibody will recognize all isoforms (SnoN, SnoN2, SnoI, and SnoA) .

• NCBI Gene ID:

  6498

• Swiss Prot:

  P12757

• Accession Number:

  NP_005405

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction, Cancer

• Purification:

  SnoN Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1202 - A431 Cell Lysate

• Concentration:

  1 mg/ml

• Buffer:

  SnoN Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  SnoN antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Symbol:

  SKIL

• Positive Control 2:

  Cat. No. 1402 - Mouse Lung Tissue Lysate

• NCBI Official Name:

  SKI-like oncogene

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Derynck R, Akhurst RJ, and Balmain A. TGF-β signaling in tumor suppression and cancer progression. Nat. Genet. 2001; 29:117-129.

• Background Reference 02:

  Li Y, Turck CM, Teumer JK, et al. Unique sequence, Ski, in Sloan-Kettering avian retrovirus with properties of a new cell-derived oncogene. J. Virol. 1986; 57:1065-72.

• Background Reference 03:

  Luo K. Ski and SnoN: negative regulators of TGF-β signaling. Curr. Op. Gen. Dev. 2004; 14:65-70.

• Background Reference 04:

  Massague J and Wotton D. Transcriptional control by the TGF-β /Smad signaling system. EMBO J. 2000; 19:1745-54.

• Other Product Names:

  SnoN Antibody: SNO, SnoA, SnoI, SnoN, SNO, Ski-like protein, Ski-related oncogene

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  223029418

• Physical Properties:

  Liquid