Brd8 (BC025644) Mouse Recombinant Protein

CAT: 0882-PM44893M5Size: 20 µgDry Ice: NoHazardous: No
CAT#:0882-PM44893M5Size:20 µg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR) . Stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.[UniProtKB/Swiss-Prot Function]
Overview
Purified recombinant protein of Mouse bromodomain containing 8 (cDNA clone MGC:36597 IMAGE:5323755), complete cds, with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Synonyms
SMAP, 4933408B17Rik
Gene ID
78656
UniProt
Q8R3B7
Accession Number mRNA
BC025644
Chromosomal Location
18 B1
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
99.3 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Brd8
Species
Mouse
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/78656
Uniprot URL
https://www.uniprot.org/uniprot/Q8R3B7
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/BC025644

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