Slc12a5 (NM_020333) Mouse Recombinant Protein

• Background:

  Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl (-) homeostasis. As major extruder of intracellular chloride, it establishes the low neuronal Cl (-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition. Involved in the regulation of dendritic spine formation and maturation.[UniProtKB/Swiss-Prot Function]

• Synonyms:

  KCC2; mKIAA1176

• Gene ID:

  57138

• UniProt:

  Q91V14, A0A076FSX1

• Accession Number mRNA:

  NM_020333

• Chromosomal Location:

  2 H3

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  124 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Slc12a5

• Species:

  Mouse

• Protein ID:

  NP_065066

• Overview:

  Purified recombinant protein of Mouse solute carrier family 12, member 5 (Slc12a5), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/57138

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q91V14

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_020333

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_065066