CXCL14 Protein, Mouse, Recombinant

• Background:

  CXCL14 is a CXC chemokine family that exhibits antimicrobial activity and contains an amphipathic cationic alpha-helical region in the C-terminus, a characteristic structure of antimicrobial peptides (AMPs) . CXCL14 is involved in cell recruitment, migration, activation, and homing in liver diseases and have been shown to be upregulated during acute liver injury in animal models. The CXC chemokine ligand 14 (CXCL14) had been show highly expressed in tumor-associated stromal cells, promoting tumor cell growth, and invasion. The stimulation of dysregulated CXCL14 expression by P. gingivalis may help promote dysbiosis and the development of chronic periodontitis. The level of CXCL14 expression may be a valuable adjuvant parameter to predict the prognosis of patients with oral carcinoma and may be a potential therapeutic target.

• Synonyms:

  1110031L23Rik Protein, Mouse; 1200006I23Rik Protein, Mouse; AI414372 Protein, Mouse; BMAC Protein, Mouse; bolekine Protein, Mouse; BRAK Protein, Mouse; Kec Protein, Mouse; KS1 Protein, Mouse; MIP-2g Protein, Mouse; MIP2gamma Protein, Mouse; NJAC Protein, Mouse; Scyb14 Protein, Mouse

• Gene Name:

  Chemokine (C-X-C motif) ligand 14

• Expression System:

  E. coli

• Tag:

  No tag

• Endotoxin:

  Please contact us for more information.

• Purity:

  > 95 % as determined by SDS-PAGE.

• Activity:

  At Leading Biology, the biological activity of a recombinant protein is routinely measured using a bioassay, e.g. chemotaxis or cell proliferation assay, enzyme assay, or a functional ELISA. When a recombinant protein is an enzyme, specific activity is derived from an enzymatic assay. Each enzyme is tested for potency by cleavage of a substrate. We are in the process of updating the biological activity data. If you have any questions regarding this update, please feel free to contact our technical support team.

• Form:

  Lyophilized

• Buffer:

  Lyophilized from sterile 100mM Na2HPO4, 1 M NaCl, pH 6.5. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.

• Function:

  Cytokine Proteins, Growth Factor proteins, Biological Target proteins

• Molecular Weight:

  The recombinant mouse Cxcl14 consists 77 amino acids and predicts a molecular mass of 9.4 kDa.

• Storage Conditions:

  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  CXCL14

• Species:

  Mouse

• Protein ID:

  NP_062514.2

• Overview:

  A DNA sequence encoding the mouse Cxcl14 (NP_062514.2) (Ser23-Glu99) was expressed.

• AA Sequence:

  Ser23-Glu99

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/protein/NP_062514.2