CDE-096

CAT: 0804-HY-120516-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-120516-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CDE-096 is a potent inhibitor of PAI-1. CDE-096 prevents PAI-1 from inactivating tPA and uPA with similar potency (IC50=30 and 25 nM, respectively) and is active against glycosylated PAI-1, as well as PAI-1 derived from several species (IC50=19, 22 and 18 nM for murine, rat, and Porcine PAI-1, respectively) [1].
CAS Number
[1228357-04-7]
UNSPSC
12352005
Target
PAI-1
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/cde-096.html
Purity
99.98
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(OC1=CC=CC(C(F)(F)F)=C1)NCC(COC(C2=CC(O)=C(C(O)=C2)O)=O)OC(C3=CC(O)=C(C(O)=C3)O)=O
Molecular Formula
C25H20F3NO12
Molecular Weight
583.42
References & Citations
[1]Li SH, et al. Mechanistic characterization and crystal structure of a small molecule inactivator bound to plasminogen activator inhibitor-1. Proc Natl Acad Sci U S A. 2013;110 (51) :E4941-E4949.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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