MMP2 Mouse Monoclonal Antibody [Clone ID: LBI4A11]

• Background:

  Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

• Synonyms:

  CLG4; CLG4A; MMP-2; MMP-II; MONA; TBE-1

• Gene Name:

  Homo sapiens matrix metallopeptidase 2 (MMP2), transcript variant 1, mRNA.

• Gene ID:

  4313

• UniProt:

  P08253

• Conjugation:

  Unconjugated

• Related Pathways:

  Bladder cancer, GnRH signaling pathway, Leukocyte transendothelial migration, Pathways in cancer

• Field of Research:

  Bladder cancer, GnRH signaling pathway, Leukocyte transendothelial migration, Pathways in cancer

• Dilution:

  WB 1:2000, IHC 1:150

• Form:

  Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

• Buffer:

  Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

• Function:

  Druggable Genome, Protease

• Storage Conditions:

  Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Symbol:

  MMP2

• Overview:

  Carrier-free (BSA/glycerol-free) MMP2 mouse monoclonal antibody, clone LBI4A11

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=4313

• Uniprot URL:

  https://www.uniprot.org/uniprot/P08253