MMP2 Antibody [AMM22109G]

• Background:

  Tissue Location: Produced by normal skin fibroblasts. PEX is expressed in a number of tumors including gliomas, breast and prostate

• Synonyms:

  72 kDa type IV collagenase, 72 kDa gelatinase, Gelatinase A, Matrix metalloproteinase-2, MMP-2, TBE-1, PEX, MMP2, CLG4A

• Gene Name:

  MMP2

• Gene ID:

  4313

• UniProt:

  P08253

• Chromosomal Location:

  [Isoform 1]: Secreted, extracellular space, extracellular matrix. Membrane. Nucleus Note=Colocalizes with integrin alphaV/beta3 at the membrane surface in angiogenic blood vessels and melanomas. Found in mitochondria, along microfibrils, and in nuclei of cardiomyocytes

• Applications:

  WB, IF, IHC-P

• Dilution:

  WB--1:500~1000 IF--1:10~50 IHC-P--1:100~500

• Form:

  Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.

• Function:

  Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta- type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14. [Isoform 2]: Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial- nuclear stress signaling with activation of the pro-inflammatory NF- kappaB, NFAT and IRF transcriptional pathways.

• Molecular Weight:

  73882

• Storage Conditions:

  Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality MMP2 Antibody [AMM22109G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=4313

• Uniprot URL:

  https://www.uniprot.org/uniprot/P08253