MMP2 Mouse Monoclonal Antibody [Clone ID: LBI4B11]

• Background:

  Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

• Synonyms:

  CLG4; CLG4A; MMP-2; MMP-II; MONA; TBE-1

• Gene Name:

  Matrix metallopeptidase 2

• Gene ID:

  4313

• UniProt:

  P08253

• Conjugation:

  Unconjugated

• Related Pathways:

  Bladder cancer, GnRH signaling pathway, Leukocyte transendothelial migration, Pathways in cancer

• Field of Research:

  Bladder cancer, GnRH signaling pathway, Leukocyte transendothelial migration, Pathways in cancer

• Concentration:

  1 mg/ml

• Dilution:

  WB 1:2000

• Form:

  PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

• Buffer:

  PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

• Function:

  Druggable Genome, Protease

• Storage Conditions:

  Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Symbol:

  MMP2

• Overview:

  MMP2 mouse monoclonal antibody, clone LBI4B11

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=4313

• Uniprot URL:

  https://www.uniprot.org/uniprot/P08253