CAF-1 Antibody (N-term) [APR30730G]

• Synonyms:

  CCR4-NOT transcription complex subunit 7, BTG1-binding factor 1, CCR4-associated factor 1, CAF-1, Caf1a, CNOT7, CAF1

• Gene Name:

  CNOT7

• Gene ID:

  29883

• UniProt:

  Q9UIV1

• Chromosomal Location:

  Nucleus. Cytoplasm, P-body. Note=NANOS2 promotes its localization to P-body.

• Applications:

  IHC-P, IF, WB

• Dilution:

  WB--1:1000 IHC-P--1:100~500 IF--1:10~50

• Form:

  Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

• Function:

  Has 3'-5' poly (A) exoribonuclease activity for synthetic poly (A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.

• Molecular Weight:

  32745

• Storage Conditions:

  Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality CAF-1 Antibody (N-term) [APR30730G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=29883

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9UIV1