CAF-1 Antibody

• Background:

  The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The protein has both mouse and yeast orthologs. Alternate splicing of this gene results in two transcript variants encoding different isoforms.

• NCBI Gene ID:

  29883

• Swiss Prot:

  Q9UIV1

• Accession Number:

  Q9UIV1

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CAF-1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 34-61 amino acids from the N-terminal region of human CAF-1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine, Chicken, Zebrafish, Mouse, Xenopus

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  33 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  CNOT7

• NCBI Official Name:

  CCR4-NOT transcription complex subunit 7

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Lau, N.C., et al. Biochem. J. 422 (3) :443-453 (2009)

• Background Reference 02:

  Aslam, A., et al. Mol. Biol. Cell 20 (17) :3840-3850 (2009)

• Background Reference 03:

  Miyasaka, T., et al. Cancer Sci. 99 (4) :755-761 (2008)

• Background Reference 04:

  Nishida, K., et al. Acta Crystallogr. Sect.Struct. Biol. Cryst. Commun. 63 (PT 12), 1061-1063 (2007) :

• Other Product Names:

  CCR4-NOT transcription complex subunit 7, BTG1-binding factor 1, CCR4-associated factor 1, CAF-1, Caf1a, CNOT7, CAF1

• Tested Applications:

  WB, IHC-P, IF

• Protein ID:

  41713629

• Physical Properties:

  Liquid