NKX2-1 Antibody (N-term) [APR30670G]

• Background:

  Tissue Location: Thyroid and lung.

• Synonyms:

  Homeobox protein Nkx-21, Homeobox protein NK-2 homolog A, Thyroid nuclear factor 1, Thyroid transcription factor 1, TTF-1, Thyroid-specific enhancer-binding protein, T/EBP, NKX2-1, NKX2A, TITF1, TTF1

• Gene Name:

  HGNC:11825

• Gene ID:

  7080

• UniProt:

  P43699

• Chromosomal Location:

  Nucleus {ECO:0000250|UniProtKB:P50220}.

• Applications:

  WB, FC

• Dilution:

  WB--1:1000 FC--1:10~50

• Form:

  Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

• Function:

  Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1 (By similarity) .

• Molecular Weight:

  38596

• Storage Conditions:

  Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality NKX2-1 Antibody (N-term) [APR30670G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=7080

• Uniprot URL:

  https://www.uniprot.org/uniprot/P43699