IL-1 beta Protein, Mouse, Recombinant

• Background:

  Interleukin-1 beta (IL1 beta or IL1B) also known as catabolin, is a member of the interleukin 1 cytokine family. IL1 is a pleiotropic cytokine. It is involved in the inflammatory response, cell growth, and tissue repair in the cortex. The IL1 superfamily consists of three members, IL1A (IL1 alpha), IL1B (IL1 beta), and IL1 receptor antagonist (IL1Ra) . In clinical, it has been reported that Interleukin (IL) -1 may influence Th1 / Th2 immune responsiveness and has been implicated in the establishment of a successful pregnancy. Proinflammatory interleukin (IL) -1 gene polymorphisms associated with high levels of IL-1beta activity increase the risk for hypochlorhydria and distal gastric carcinoma. IL1B polymorphisms may be involved in susceptibility to SSc. Moreover, the IL2-384-G allele may be a marker for the limited phenotype of systemic sclerosis (SSc) .

• Synonyms:

  Il-1b Protein, Mouse; IL-1beta Protein, Mouse

• Gene Name:

  Interleukin 1, beta

• UniProt:

  P10749

• Expression System:

  E. coli

• Tag:

  No tag

• Field of Research:

  Neuroinflammation

• Endotoxin:

  Please contact us for more information.

• Purity:

  > 97 % as determined by SDS-PAGE.

• Activity:

  1. Measured by its ability to induce Interferon gamma secretion by human natural killer lymphoma NK-92 cells. The EDfor this effect is typically 6-30 ng/mL.

• Form:

  Lyophilized

• Buffer:

  Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.

• Function:

  Cytokine Proteins, Growth Factor proteins, Interleukin proteins, Cell Therapy proteins, Diagnostic proteins, Immunotherapy proteins, Biomarker Proteins, Biological Target proteins

• Molecular Weight:

  The recombinant mouse IL1β consists of 153 amino acids and has a predicted molecular mass of 17.5 kDa. It migrates as an approximately 19 kDa band in SDS-PAGE under reducing conditions as predicted.

• Storage Conditions:

  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  IL1B

• Species:

  Mouse

• Overview:

  A DNA sequence encoding the mature form of mouse IL1β (P10749) (Val 118-Ser 269) was expressed, with an initial Met at the C-terminus.

• Uniprot URL:

  https://www.uniprot.org/uniprot/P10749

• AA Sequence:

  Val118-Ser269