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3-Chlorodiphenylamine

CAT: 0804-HY-131948-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-131948-01Size:100 mg
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Description
3-Chlorodiphenylamine is a high affinity Ca2+ sensitizer of cardiac muscle. 3-Chlorodiphenylamine is based on diphenylamine and binds to the isolated N-domain of cardiac troponin C (cTnC) (Kd=6 μM) . 3-Chlorodiphenylamine is an excellent starting scaffold for the development of more potent Ca2+-sensitizing compounds due to its small size, and can be used for systolic heart failure research[1].
CAS Number
101-17-7
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/3-chlorodiphenylamine.html
Concentration
10mM
Purity
98.74
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
ClC1=CC(NC2=CC=CC=C2)=CC=C1
Molecular Formula
C12H10ClN
Molecular Weight
203.67
Precautions
H315, H319, H320
References & Citations
[1]Svetlana B Tikunova, et al. 3-Chlorodiphenylamine activates cardiac troponin by a mechanism distinct from bepridil or TFP. J Gen Physiol. 2019 Jan 7;151 (1) :9-17.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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