Oxolinic acid

• Description :

  Oxolinic acid is an antibiotic against both Gram-negative and Gram-positive bacteria. Oxolinic acid can be used for the research of acute and chronic urinary tract infections. Oxolinic acid is a DNA/RNA synthesis inhibitor. Oxolinic acid acts a dopamine uptake inhibitor and stimulants locomotor effect in mice[1][2][3].

• UNSPSC :

  12352005

• Hazard Statement :

  H302

• Target :

  Antibiotic; Bacterial; DNA/RNA Synthesis

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; Cell Cycle/DNA Damage

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/Oxolinic-acid.html

• Purity :

  99.10

• Solubility :

  0.5 M NaOH : ≥ 50 mg/mL|DMSO : 1 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

• Smiles :

  O=C(C1=CN(CC)C2=C(C=C3C(OCO3)=C2)C1=O)O

• Molecular Formula :

  C13H11NO5

• Molecular Weight :

  261.23

• Precautions :

  H302

• References & Citations :

  [1]M J Kershaw, et al. The antibacterial and pharmacological activity of oxolinic acid (Prodoxol) . J Antimicrob Chemother. 1975 Sep;1 (3) :311-5.|[2]S H Manes, et al. Inhibition of RNA synthesis by oxolinic acid is unrelated to average DNA supercoiling. J Bacteriol. 1983 Jul; 155 (1) : 420-423.|[3]J Garcia de Mateos-Verchere, et al. Behavioural and neurochemical evidence that the antimicrobial agent oxolinic acid is a dopamine uptake inhibitor. Eur Neuropsychopharmacol. 1998 Dec;8 (4) :255-9.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [14698-29-4]