Oxolinic acid-d5

• UNSPSC Description:

  Oxolinic acid-d5 is the deuterium labeled Oxolinic acid. Oxolinic acid is an antibiotic against both Gram-negative and Gram-positive bacteria. Oxolinic acid can be used for the research of acute and chronic urinary tract infections. Oxolinic acid is a DNA/RNA synthesis inhibitor. Oxolinic acid acts a dopamine uptake inhibitor and stimulants locomotor effect in mice[1][2][3].

• Target Antigen:

  Antibiotic; Bacterial; DNA/RNA Synthesis; Isotope-Labeled Compounds

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Anti-infection;Cell Cycle/DNA Damage;Others

• Field of Research:

  Infection

• Purity:

  98.0

• Solubility:

  10 mM in DMSO

• Smiles:

  [2H]C([2H])([2H])C([2H])([2H])N1C2=C(C(C(C(O)=O)=C1)=O)C=C3C(OCO3)=C2

• Molecular Weight:

  266.26

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]M J Kershaw, et al. The antibacterial and pharmacological activity of oxolinic acid (Prodoxol). J Antimicrob Chemother. 1975 Sep;1(3):311-5.|[3]S H Manes, et al. Inhibition of RNA synthesis by oxolinic acid is unrelated to average DNA supercoiling. J Bacteriol. 1983 Jul; 155(1): 420-423.|[4]J Garcia de Mateos-Verchere, et al. Behavioural and neurochemical evidence that the antimicrobial agent oxolinic acid is a dopamine uptake inhibitor. Eur Neuropsychopharmacol. 1998 Dec;8(4):255-9.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  1189890-98-9