Oxolinic acid-d5

• Description :

  Oxolinic acid-d5 is the deuterium labeled Oxolinic acid. Oxolinic acid is an antibiotic against both Gram-negative and Gram-positive bacteria. Oxolinic acid can be used for the research of acute and chronic urinary tract infections. Oxolinic acid is a DNA/RNA synthesis inhibitor. Oxolinic acid acts a dopamine uptake inhibitor and stimulants locomotor effect in mice[1][2][3].

• UNSPSC :

  12352005

• Hazard Statement :

  H302

• Target :

  Antibiotic; Bacterial; DNA/RNA Synthesis; Isotope-Labeled Compounds

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Anti-infection; Cell Cycle/DNA Damage; Others

• Field of Research :

  Infection

• Purity :

  98.0

• Solubility :

  10 mM in DMSO

• Smiles :

  [2H]C([2H])([2H])C([2H])([2H])N1C2=C(C(C(C(O)=O)=C1)=O)C=C3C(OCO3)=C2

• Molecular Formula :

  C13H6D5NO5

• Molecular Weight :

  266.26

• Precautions :

  P264-P270-P330-P501

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]M J Kershaw, et al. The antibacterial and pharmacological activity of oxolinic acid (Prodoxol) . J Antimicrob Chemother. 1975 Sep;1 (3) :311-5.|[3]S H Manes, et al. Inhibition of RNA synthesis by oxolinic acid is unrelated to average DNA supercoiling. J Bacteriol. 1983 Jul; 155 (1) : 420-423.|[4]J Garcia de Mateos-Verchere, et al. Behavioural and neurochemical evidence that the antimicrobial agent oxolinic acid is a dopamine uptake inhibitor. Eur Neuropsychopharmacol. 1998 Dec;8 (4) :255-9.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported

• CAS Number :

  [1189890-98-9]