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HR-19011

CAT: 0804-HY-147831-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-147831-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HR-19011 (Compound 40) is an activator of eukaryotic initiation factor 2 alpha (eIF2α) phosphorylation. HR-19011 increases the expression level of eIF2α downstream proteins, ATF and CHOP. HR-19011 exhibits antiproliferative activity againist K562 and PBMC cells with IC50s of 4.00 and 19.3 μM, respectively[1].
CAS Number
2851820-52-3
UNSPSC
12352005
Target
Eukaryotic Initiation Factor (eIF)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/eif2α-activator-1.html
Purity
99.64
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
N#CC1=CC(C(F)(F)F)=CC(NC2=C(C(C2=O)=O)N[C@@H]3CC[C@@H](OC4=CC=C(C=C4)C(F)(F)F)CC3)=C1
Molecular Formula
C25H19F6N3O3
Molecular Weight
523.43
References & Citations
[1]Jinsook Kwak, et al. A bioisosteric approach to the discovery of novel N-aryl-N'-[4- (aryloxy) cyclohexyl]squaramide-based activators of eukaryotic initiation factor 2 alpha (eIF2α) phosphorylation. Eur J Med Chem. 2022 May 29;239:114501.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EIF2

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