BC-1901S

• UNSPSC Description:

  BC-1901S is a proteasome-independent NRF2 activator and stabilizer. BC-1901S binds to DCAF1 (E3 ligase subunit) and disrupts NRF2/DCAF1 interaction, and activates NRF2 by inhibiting NRF2 ubiquitination in a KEAP1-independent manner. BC-1901S shows anti-inflammatory effect in a murine model of LPS-induced acute lung injury[1].

• Target Antigen:

  E1/E2/E3 Enzyme; Keap1-Nrf2

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease;NF-κB

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/bc-1901s.html

• Smiles:

  O=C(C1CCN(CC1)C2=NC(C3=CC(C)=CC=C3)=NC=C2)NC4=CC=C(C(Cl)=C4)F

• Molecular Weight:

  424.90

• References & Citations:

  [1]Chen Y, et al. A small molecule NRF2 activator BC-1901S ameliorates inflammation through DCAF1/NRF2 axis. Redox Biol. 2020 May;32:101485.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1358617-36-3