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SJG-136 intermediate-1

CAT: 0804-HY-402091-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-402091-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SJG-136 intermediate-1 (compound 19) is an intermediate for synthesizing SJG-136. SJG-136 is a DNA cross-linking agent, with an XL50 of 45 nM for pBR322 DNA[1].
CAS Number
232931-64-5
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
ADC Payload
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/sjg-136-intermediate-1.html
Purity
99.95
Smiles
C=CCOC(N1C2=CC(OCCCOC3=C(OC)C=C(C(N4[C@](CC(C4)=C)([H])[C@@H](N5C(OCC=C)=O)O)=O)C5=C3)=C(OC)C=C2C(N6[C@](CC(C6)=C)([H])[C@@H]1O)=O)=O
Molecular Formula
C39H44N4O12
Molecular Weight
760.79
Precautions
H302, H315, H319, H335
References & Citations
[1]S J Gregson, et al. Design, synthesis, and evaluation of a novel pyrrolobenzodiazepine DNA-interactive agent with highly efficient cross-linking ability and potent cytotoxicity. J Med Chem. 2001 Mar 1;44 (5) :737-48.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
ADC Related
Clinical Information
No Development Reported

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