14-Deoxyandrographolide

• Description :

  14-Deoxyandrographolide is a diterpene with calcium channel blocking activity and acts as a uterine smooth muscle relaxant. 14-Deoxyandrographolide stimulates the release of nitric oxide (NO) in endothelial cells. 14-Deoxyandrographolide gradually desensitizes liver cells to TNF-α mediated apoptosis by inducing the release of TNFRSF1A[1][2][3].

• UNSPSC :

  12352005

• Target :

  Apoptosis; Calcium Channel; Caspase

• Type :

  Natural Products

• Related Pathways :

  Apoptosis; Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Metabolic Disease; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/14-deoxyandrographolide.html

• Purity :

  99.94

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C1OCC=C1CC[C@@H]2C(CC[C@]3([H])[C@](C)(CO)[C@H](O)CC[C@@]23C)=C

• Molecular Formula :

  C20H30O4

• Molecular Weight :

  334.45

• References & Citations :

  [1]Roy DN, et al. 14-Deoxyandrographolide desensitizes hepatocytes to tumour necrosis factor-alpha-induced apoptosis through calcium-dependent tumour necrosis factor receptor superfamily member 1A release via the NO/cGMP pathway. Br J Pharmacol. 2010 Aug;160 (7) :1823-43.|[2]Burgos RA, et al. Effect of 14-deoxyandrographolide on calcium-mediated rat uterine smooth muscle contractility. Phytother Res. 2003;17 (9) :1011-1015.|[3]C Y Zhang, et al. Effects of 14-deoxyandrographolide and 14-deoxy-11,12-didehydroandrographolide on nitric oxide production in cultured human endothelial cells. Phytother Res. 1999 Mar;13 (2) :157-9.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• Isoform :

  Caspase 3

• CAS Number :

  [4176-97-0]