Biphalin (TFA)

• Description:

  Biphalin TFA, a BBB-penetrable opioid peptide analog, contains two active enkephalin pharmacophores. Biphalin TFA has high affinity for opioid receptors. Biphalin TFA shows analgesic effect in acute, neuropathic, and chronic animal pain models. Biphalin TFA is also an antiviral, antiproliferative, anti-inflammatory, and neuroprotective agent[1].

• UNSPSC:

  12352209

• Target:

  Opioid Receptor

• Type:

  Peptides

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/biphalin-tfa.html

• Solubility:

  10 mM in DMSO

• Smiles:

  OC(C=C1)=CC=C1C[C@H](N)C(N[C@H](C)C(NCC(N[C@@H](CC2=CC=CC=C2)C(NNC([C@@H](NC(CNC([C@@H](C)NC([C@@H](N)CC3=CC=C(C=C3)O)=O)=O)=O)CC4=CC=CC=C4)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O.[x]

• Molecular Formula:

  C46H56N10O10·xC2HF3O2

• Molecular Weight:

  909.00 (free base)

• References & Citations:

  [1]T J Abbruscato, et al. Blood-to-central nervous system entry and stability of biphalin, a unique double-enkephalin analog, and its halogenated derivatives. J Pharmacol Exp Ther. 1996, 276,3.|[2]Redkiewicz P, et al. Biphalin-A Potent Opioid Agonist-As a Panacea for Opioid System-Dependent Pathophysiological Diseases? Int J Mol Sci. 2021 Oct 21;22 (21) :11347.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported

• CAS Number:

  [126872-95-5]