Coenzyme FO

• Description:

  Coenzyme FO, a deazaflavin chromophore, acts as an important hydride acceptor/donor in the central methanogenic pathway[1][2].

• UNSPSC:

  12352005

• Target:

  Bacterial; Endogenous Metabolite

• Type:

  Reference compound

• Related Pathways:

  Anti-infection; Metabolic Enzyme/Protease

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/coenzyme-f420-1.html

• Purity:

  98.90

• Solubility:

  DMSO : 10 mg/mL (ultrasonic) |Ethanol : < 1 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  O[C@H]([C@H](O)[C@H](O)CO)CN(C1=CC(O)=CC=C1C=C2C(N3)=O)C2=NC3=O

• Molecular Formula:

  C16H17N3O7

• Molecular Weight:

  363.32

• References & Citations:

  [1]Purwantini E, et al. Conversion of NO2 to NO by reduced coenzyme F420 protects mycobacteria from nitrosative damage. Proc Natl Acad Sci U S A. 2009;106 (15) :6333‐6338.|[2]Mills DJ, et al. De novo modeling of the F (420) -reducing [NiFe]-hydrogenase from a methanogenic archaeon by cryo-electron microscopy. Elife. 2013;2:e00218. Published 2013 Mar 5.|[3]de Poorter LMI, et al. Hydrogen concentrations in methane-forming cells probed by the ratios of reduced and oxidized coenzyme F420. Microbiology. 2005;151 (Pt 5) :1697‐1705.|[4]Philmus B, et al. Biosynthetic versatility and coordinated action of 5'-deoxyadenosyl radicals in deazaflavin biosynthesis. J Am Chem Soc. 2015;137 (16) :5406-5413.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [37333-48-5]