Coenzyme FO

• UNSPSC Description:

  Coenzyme FO, a deazaflavin chromophore, acts as an important hydride acceptor/donor in the central methanogenic pathway[1][2].

• Target Antigen:

  Bacterial; Endogenous Metabolite

• Type:

  Reference compound

• Related Pathways:

  Anti-infection;Metabolic Enzyme/Protease

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/coenzyme-f420-1.html

• Smiles:

  O[C@H]([C@H](O)[C@H](O)CO)CN(C1=CC(O)=CC=C1C=C2C(N3)=O)C2=NC3=O

• Molecular Weight:

  363.32

• References & Citations:

  [1]Purwantini E, et al. Conversion of NO2 to NO by reduced coenzyme F420 protects mycobacteria from nitrosative damage. Proc Natl Acad Sci U S A. 2009;106(15):6333‐6338.|[2]Mills DJ, et al. De novo modeling of the F(420)-reducing [NiFe]-hydrogenase from a methanogenic archaeon by cryo-electron microscopy. Elife. 2013;2:e00218. Published 2013 Mar 5.|[3]de Poorter LMI, et al. Hydrogen concentrations in methane-forming cells probed by the ratios of reduced and oxidized coenzyme F420. Microbiology. 2005;151(Pt 5):1697‐1705.|[4]Philmus B, et al. Biosynthetic versatility and coordinated action of 5'-deoxyadenosyl radicals in deazaflavin biosynthesis. J Am Chem Soc. 2015;137(16):5406-5413.

• Shipping Conditions:

  Room Temperature

• CAS Number:

  37333-48-5