Coenzyme FO

CAT: 0804-HY-136497-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-136497-01Size:5 mg
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Description
Coenzyme FO, a deazaflavin chromophore, acts as an important hydride acceptor/donor in the central methanogenic pathway[1][2].
CAS Number
[37333-48-5]
UNSPSC
12352005
Target
Bacterial; Endogenous Metabolite
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/coenzyme-f420-1.html
Purity
98.90
Solubility
DMSO : 10 mg/mL (ultrasonic) |Ethanol : < 1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O[C@H]([C@H](O)[C@H](O)CO)CN(C1=CC(O)=CC=C1C=C2C(N3)=O)C2=NC3=O
Molecular Formula
C16H17N3O7
Molecular Weight
363.32
References & Citations
[1]Purwantini E, et al. Conversion of NO2 to NO by reduced coenzyme F420 protects mycobacteria from nitrosative damage. Proc Natl Acad Sci U S A. 2009;106 (15) :6333‐6338.|[2]Mills DJ, et al. De novo modeling of the F (420) -reducing [NiFe]-hydrogenase from a methanogenic archaeon by cryo-electron microscopy. Elife. 2013;2:e00218. Published 2013 Mar 5.|[3]de Poorter LMI, et al. Hydrogen concentrations in methane-forming cells probed by the ratios of reduced and oxidized coenzyme F420. Microbiology. 2005;151 (Pt 5) :1697‐1705.|[4]Philmus B, et al. Biosynthetic versatility and coordinated action of 5'-deoxyadenosyl radicals in deazaflavin biosynthesis. J Am Chem Soc. 2015;137 (16) :5406-5413.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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