Argatroban-13C6 (hydrochloride)

• UNSPSC Description:

  Argatroban-13C6 hydrochloride is 13C labeled Argatroban (HY-B0375). Argatroban (MD-805) is a direct, selective thrombin inhibitor.

• Target Antigen:

  Isotope-Labeled Compounds; Thrombin

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Metabolic Enzyme/Protease;Others

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/argatroban-13c6-hydrochloride.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C([C@@H]1N(C([C@@H](NS(=O)([13C]2=[13CH][13CH]=[13CH][13C]3=[13C]2NCC(C)C3)=O)CCCNC(N)=N)=O)CC[C@@H](C)C1)O.Cl

• Molecular Weight:

  551.05

• References & Citations:

  [1]Kawada, T., et al., Argatroban, an attractive anticoagulant, for left heart bypass with centrifugal pump for repair of traumatic aortic rupture. Jpn J Thorac Cardiovasc Surg, 1999. 47(3): p. 104-9.|[2]Jang, I.K., et al., A multicenter, randomized study of argatroban versus heparin as adjunct to tissue plasminogen activator (TPA) in acute myocardial infarction: myocardial infarction with novastan and TPA (MINT) study. J Am Coll Cardiol, 1999. 33(7): p. 1879-85.|[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported