Doxofylline-d4

• Description :

  Doxofylline-d4 is the deuterium labeled Doxofylline. Doxofylline is an antagonist of adenosine A1 receptor which also inhibits phosphodiesterase IV[1][2].

• UNSPSC :

  12352005

• Target :

  Adenosine Receptor; Isotope-Labeled Compounds; Phosphodiesterase (PDE)

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  GPCR/G Protein; Metabolic Enzyme/Protease; Others

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Solubility :

  10 mM in DMSO

• Smiles :

  C(N1C2=C(N(C)C(=O)N(C)C2=O)N=C1)C3OC(C(O3)([2H])[2H])([2H])[2H]

• Molecular Formula :

  C11H10D4N4O4

• Molecular Weight :

  270.28

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Shukla D, et al. Doxofylline: a promising methylxanthine derivative for the treatment of asthma and chronic obstructive pulmonary disease. Expert Opin Pharmacother. 2009 Oct;10 (14) :2343-56.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported

• CAS Number :

  [1346599-13-0]