Doxofylline-d6

• Description :

  Doxofylline-d6 is the deuterium labeled Doxofylline. Doxofylline is an antagonist of adenosine A1 receptor which also inhibits phosphodiesterase IV.

• CAS Number :

  [1219805-99-8]

• UNSPSC :

  12352005

• Target :

  Adenosine Receptor; Phosphodiesterase (PDE)

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  GPCR/G Protein; Metabolic Enzyme/Protease

• Field of Research :

  Inflammation/Immunology

• Purity :

  99.61

• Solubility :

  10 mM in DMSO|DMSO : 50mg/mL (ultrasonic) |H2O : 25mg/mL (ultrasonic)

• Smiles :

  O=C1C2=C(N=CN2CC3OCCO3)N(C([2H])([2H])[2H])C(N1C([2H])([2H])[2H])=O

• Molecular Formula :

  C11H8D6N4O4

• Molecular Weight :

  272.29

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Shukla D, et al. Doxofylline: a promising methylxanthine derivative for the treatment of asthma and chronic obstructive pulmonary disease. Expert Opin Pharmacother. 2009 Oct;10 (14) :2343-56.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported