Doxofylline-d6

• Description:

  Doxofylline-d6 is the deuterium labeled Doxofylline. Doxofylline is an antagonist of adenosine A1 receptor which also inhibits phosphodiesterase IV.

• UNSPSC:

  12352005

• Target:

  Adenosine Receptor; Phosphodiesterase (PDE)

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  GPCR/G Protein; Metabolic Enzyme/Protease

• Field of Research:

  Inflammation/Immunology

• Purity:

  99.61

• Solubility:

  10 mM in DMSO|DMSO : 50mg/mL (ultrasonic) |H2O : 25mg/mL (ultrasonic)

• Smiles:

  O=C1C2=C(N=CN2CC3OCCO3)N(C([2H])([2H])[2H])C(N1C([2H])([2H])[2H])=O

• Molecular Formula:

  C11H8D6N4O4

• Molecular Weight:

  272.29

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Shukla D, et al. Doxofylline: a promising methylxanthine derivative for the treatment of asthma and chronic obstructive pulmonary disease. Expert Opin Pharmacother. 2009 Oct;10 (14) :2343-56.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• CAS Number:

  1219805-99-8