TDO-IN-1

TDO-IN-1

• CAS Number: 2490672-92-7
• UNSPSC Description: TDO-IN-1 is an orally active and selective inhibitor of tryptophan 2,3-dioxygenase (TDO), shows excellent selectivity over indoleamine-2,3-dioxygenase (IDO), with an IC50 value of 0.62 μM (IDO). TDO-IN-1 reverse the local immune tolerance of tumor tissue to inhibit tumor growth in vivo[1].
• Target Antigen: Indoleamine 2,3-Dioxygenase (IDO)
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/tdo-in-1.html
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: FC(C1=CC2=C(C(NCC3=CC=C(C)C=C3[N+]([O-])=O)=C1)C=NN2)(F)F
• Molecular Weight: 350.30
• References & Citations: [1]Huo C, et al. 4,6-Disubstituted-1H-Indazole-4-Amine derivatives with immune-chemotherapy effect and in vivo antitumor activity. Eur J Med Chem. 2022 Nov 5;241:114625.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported