IDO/TDO-IN-1

IDO/TDO-IN-1

• CAS Number: 2033173-01-0
• UNSPSC Description: IDO/TDO-IN-1 (compound 25) is a highly potent and orally active dual indoleamine-2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) inhibitor with IC50s of 9.7 and 47 nM, respectively [1].
• Target Antigen: Indoleamine 2,3-Dioxygenase (IDO)
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/ido-tdo-in-1.html
• Purity: 99.22
• Solubility: DMSO : 30 mg/mL (ultrasonic;adjust pH to 2 with HCl)
• Smiles: CN1N=CC(C2=CC=C(N3CCC([C@@H](C4=C5C=CC=C4F)N6C5=CN=C6)CC3)C=C2)=C1
• Molecular Weight: 413.49
• References & Citations: [1]Tu W, et al. Discovery of Imidazoisoindole Derivatives as Highly Potent and Orally Active Indoleamine-2,3-dioxygenase Inhibitors. ACS Med Chem Lett. 2019 Jun 3;10(6):949-953.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture and light)
• Clinical Information: No Development Reported