Rhodblock 1a

CAT: 0804-HY-134913Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-134913Size:1 Each
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Description
Rhodblock 1a is an inhibitor of the Rho kinase signaling pathway. It inhibits the normal formation of the cleavage furrow during cell division by interfering with the localization and function of Rho pathway proteins, causing some cells to fail to form a cleavage furrow or the formed cleavage furrow to break, resulting in binucleated cells. Rhodblock 1a can be used to study the mechanism of cell division and is expected to be used in the research of diseases such as cardiovascular diseases and cancer[1].
CAS Number
[701226-08-6]
UNSPSC
12352005
Hazard Statement
H301-H413
Target
ROCK
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Cardiovascular Disease
Smiles
O=C(N1N=C(C2=CC=CC=C2)CC1C3=CC=CC=C3)C4=CC=CO4
Molecular Formula
C20H16N2O2
Molecular Weight
316.35
Precautions
P264-P270-P273-P330-P405-P501
References & Citations
[1]Castoreno AB, et al. Small molecules discovered in a pathway screen target the Rho pathway in cytokinesis. Nat Chem Biol. 2010 Jun;6 (6) :457-63.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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