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Rhodblock 1a

CAT: 0804-HY-134913Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-134913Size:1 Each
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Description
Rhodblock 1a is an inhibitor of the Rho kinase signaling pathway. It inhibits the normal formation of the cleavage furrow during cell division by interfering with the localization and function of Rho pathway proteins, causing some cells to fail to form a cleavage furrow or the formed cleavage furrow to break, resulting in binucleated cells. Rhodblock 1a can be used to study the mechanism of cell division and is expected to be used in the research of diseases such as cardiovascular diseases and cancer[1].
CAS Number
701226-08-6
UNSPSC
12352005
Hazard Statement
H301-H413
Target
ROCK
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Cardiovascular Disease
Smiles
O=C(N1N=C(C2=CC=CC=C2)CC1C3=CC=CC=C3)C4=CC=CO4
Molecular Formula
C20H16N2O2
Molecular Weight
316.35
Precautions
P264-P270-P273-P330-P405-P501
References & Citations
[1]Castoreno AB, et al. Small molecules discovered in a pathway screen target the Rho pathway in cytokinesis. Nat Chem Biol. 2010 Jun;6 (6) :457-63.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Rhodblock 1a
CAS Number701226-08-6
PubChem CID2952118
IUPAC Name(3,5-diphenyl-3,4-dihydropyrazol-2-yl)-(furan-2-yl)methanone
Molecular FormulaC20H16N2O2
Molecular Weight316.4
XLogP3.8
Topological Polar Surface Area45.8
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Heavy Atom Count24
Formal Charge0
Complexity478
SMILES
C1C(N(N=C1C2=CC=CC=C2)C(=O)C3=CC=CO3)C4=CC=CC=C4
InChI
InChI=1S/C20H16N2O2/c23-20(19-12-7-13-24-19)22-18(16-10-5-2-6-11-16)14-17(21-22)15-8-3-1-4-9-15/h1-13,18H,14H2
InChIKey
VEIXLXIVAMCBLZ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Rhodblock 1a
CAS: 701226-08-6
CID: 2952118
Formula: C20H16N2O2
MW: 316.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight316.4
XLogP33.8
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Exact Mass316.121177757
Monoisotopic Mass316.121177757
Topological Polar Surface Area45.8 Ų
Heavy Atom Count24
Formal Charge0
Complexity478
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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