TNIR7-1A

• Description :

  TNIR7-1A is a fused cycloheptatriene–BODIPY derivative that displays properties favorable for near-infrared (NIR) imaging (Ex/Em = 600/774 nm in PBS) with high affinity and specificity to Neurofibrillary tangles (NFTs) in vitro. TNIR7-1A effectively penetrated the blood–brain barrier[1].

• CAS Number :

  [2301931-35-9]

• UNSPSC :

  12352005

• Target :

  Tau Protein

• Related Pathways :

  Neuronal Signaling

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer; Neurological Disease

• Smiles :

  [F-][B+3]1([N-]2C3=C(C=C2)C=CC(/C=C/C4=CC=C(C=C4)N(C)C)=CC3=C5[N]1=CC=C5)[F-]

• Molecular Formula :

  C23H20BF2N3

• Molecular Weight :

  387.23

• References & Citations :

  [1]Tianxin Xie, et al. Fused Cycloheptatriene-BODIPY Is a High-Performance Near-Infrared Probe to Image Tau Tangles. J Med Chem. 2022 Nov 10;65 (21) :14527-14538.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported