EBV lytic cycle inducer-1

CAT: 0804-HY-149577-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-149577-01Size:5 mg
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Description
Epstein-Barr virus (EBV) lytic cycle inducer-1 Dp44mT (compound C7) is an iron-chelatoe-like compound. Dp44mT cooperates with HDAC inhibitor Romidespin (HY-15149) and SAHA to induce EBV lytic cycle. Dp44mT reactivates EBV lytic cycle by activating the ERK1/2-autophagy axis in epithelial cancers[1][2].
CAS Number
[394668-43-0]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
EBV
Type
Reference compound
Related Pathways
Anti-infection
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ebv-lytic-cycle-inducer-1.html
Purity
98.27
Solubility
DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=CC(Br)=CC=C1)N/N=C(C)/C2=NC=CC=C2
Molecular Formula
C14H12BrN3O
Molecular Weight
318.17
Precautions
H302, H315, H319, H335
References & Citations
[1]Chung King Choi, et al. Identification of Novel Small Organic Compounds with Diverse Structures for the Induction of Epstein-Barr Virus (EBV) Lytic Cycle in EBV-Positive Epithelial Malignancies. PLoS One. 2015 Dec 30;10 (12) :e0145994.|[2]Stephanie Pei Tung Yiu, et al. Intracellular Iron Chelation by a Novel Compound, C7, Reactivates Epstein–Barr Virus (EBV) Lytic Cycle via the ERK-Autophagy Axis in EBV-Positive Epithelial Cancers Cancers 2018 Dec; 10 (12) : 505.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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