Ro 23-3423

• Description :

  Ro 23-3423 is a thromboxane synthase inhibitor with an IC50 value of 0.33 μM for human platelet microsomal thromboxane synthase. Ro 23-3423 increases plasma levels of PGF and PGE2 in a dose-dependent manner, accompanied by a decrease in mean systemic arterial pressure and systemic vascular resistance. Ro 23-3423 can be used in the study of general anesthesia[1].

• UNSPSC :

  12352005

• Target :

  Prostaglandin Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/ro-23-3423.html

• Smiles :

  O=C(NC(CCCC1=CC=CN=C1)C)C2=CN(C(C=C2)=N3)C=C4C3=CC=CC4=O

• Molecular Formula :

  C23H22N4O2

• Molecular Weight :

  386.45

• References & Citations :

  [1]Morel D R, et al. Dose-dependent effects of a pyridoquinazoline thromboxane synthetase inhibitor on arachidonic acid metabolites and hemodynamics during E. coli endotoxemia in anesthetized sheep[J]. Prostaglandins, 1987, 33 (6) : 879-902.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [110996-51-5]