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Ro 23-3423

CAT: 0804-HY-118765Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-118765Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ro 23-3423 is a thromboxane synthase inhibitor with an IC50 value of 0.33 μM for human platelet microsomal thromboxane synthase. Ro 23-3423 increases plasma levels of PGF and PGE2 in a dose-dependent manner, accompanied by a decrease in mean systemic arterial pressure and systemic vascular resistance. Ro 23-3423 can be used in the study of general anesthesia[1].
CAS Number
110996-51-5
UNSPSC
12352005
Target
Prostaglandin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ro-23-3423.html
Smiles
O=C(NC(CCCC1=CC=CN=C1)C)C2=CN(C(C=C2)=N3)C=C4C3=CC=CC4=O
Molecular Formula
C23H22N4O2
Molecular Weight
386.45
References & Citations
[1]Morel D R, et al. Dose-dependent effects of a pyridoquinazoline thromboxane synthetase inhibitor on arachidonic acid metabolites and hemodynamics during E. coli endotoxemia in anesthetized sheep[J]. Prostaglandins, 1987, 33 (6) : 879-902.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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