ASM-IN-3

• Description :

  ASM-IN-3 (Compound 21b) is a selective and BBB-penetrating acid sphingomyelinase (ASM) inhibitor (IC50: 3.37 μM for pure human ASM) . ASM-IN-3 improves depression-like behaviors by inhibiting ASM activity and increasing neurogenesis in hippocampus in Reserpine (HY-N0480) -induced depressed rats[1].

• CAS Number :

  [2342576-75-2]

• UNSPSC :

  12352005

• Target :

  Phospholipase

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/asm-in-3.html

• Smiles :

  O=C(C1=CC(OCC2=CC=C(C3=CC=C(Cl)C=C3)C=C2)=NO1)NO

• Molecular Formula :

  C17H13ClN2O4

• Molecular Weight :

  344.75

• References & Citations :

  [1]Yang K, et al.. Discovery of Potent, Selective, and Direct Acid Sphingomyelinase Inhibitors with Antidepressant Activity. J Med Chem. 2020 Feb 13;63 (3) :961-974.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported