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ASM-IN-3

CAT: 0804-HY-171033Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-171033Size:1 Each
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Description
ASM-IN-3 (Compound 21b) is a selective and BBB-penetrating acid sphingomyelinase (ASM) inhibitor (IC50: 3.37 μM for pure human ASM). ASM-IN-3 improves depression-like behaviors by inhibiting ASM activity and increasing neurogenesis in hippocampus in Reserpine -induced depressed rats[1].
CAS Number
2342576-75-2
UNSPSC
12352005
Target
Phospholipase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/asm-in-3.html
Smiles
O=C(C1=CC(OCC2=CC=C(C3=CC=C(Cl)C=C3)C=C2)=NO1)NO
Molecular Formula
C17H13ClN2O4
Molecular Weight
344.75
References & Citations
[1]Yang K, et al.. Discovery of Potent, Selective, and Direct Acid Sphingomyelinase Inhibitors with Antidepressant Activity. J Med Chem. 2020 Feb 13;63 (3) :961-974.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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