ASM-IN-3

• Target:

  Phospholipase

• Related Pathways:

  Metabolism

• Bioactivity:

  ASM-IN-3 (Compound 21b) is a selective acid sphingomyelinase (ASM) inhibitor that can penetrate the blood-brain barrier, with an IC50 of 3.37 ?M against purified human ASM. By inhibiting ASM activity in the hippocampus and promoting neurogenesis, ASM-IN-3 alleviates depressive-like behavior in reserpine-induced depressive rats.

• Smiles:

  O=C(NO)C=1ON=C(OCC2=CC=C(C=C2)C=3C=CC(Cl)=CC3)C1

• Molecular Formula:

  C17H13ClN2O4

• Molecular Weight:

  344.75

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2342576-75-2