ASM-IN-2

• Description :

  ASM-IN-2 (Compound 46) is a potent ASM inhibitor with an IC50 value of 0.87 μM, displaying good drug-like properties. ASM-IN-2 involves in multiple antidepressant mechanisms of actionin, which are associated with a decline of ceramide. It demostrates remarkable antidepressant effects in the CUMS-induced mouse, which is promising for research in the field of antidepressant drugs[1].

• UNSPSC :

  12352005

• Target :

  Phospholipase

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/asm-in-2.html

• Smiles :

  O=C(C1=NN(C(C2=CC=C(C=C2)Br)=C1)C3=CC=C(C=C3)Cl)NO

• Molecular Formula :

  C16H11BrClN3O2

• Molecular Weight :

  392.63

• References & Citations :

  [1]Shi S, et al. Discovery of a Novel ASM Direct Inhibitor with a 1,5-Diphenyl-pyrazole Scaffold and Its Antidepressant Mechanism of Action[J]. J Med Chem. 2024 Jun 18:1520-4804.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Phospholipase C

• CAS Number :

  [2305789-66-4]