ASM-IN-2

• UNSPSC Description:

  ASM-IN-2 (Compound 46) is a potent ASM inhibitor with an IC50 value of 0.87 μM, displaying good drug-like properties. ASM-IN-2 involves in multiple antidepressant mechanisms of actionin, which are associated with a decline of ceramide. It demostrates remarkable antidepressant effects in the CUMS-induced mouse, which is promising for research in the field of antidepressant drugs[1].

• Target Antigen:

  Phospholipase

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/asm-in-2.html

• Smiles:

  O=C(C1=NN(C(C2=CC=C(C=C2)Br)=C1)C3=CC=C(C=C3)Cl)NO

• Molecular Weight:

  392.63

• References & Citations:

  [1]Shi S, et al. Discovery of a Novel ASM Direct Inhibitor with a 1,5-Diphenyl-pyrazole Scaffold and Its Antidepressant Mechanism of Action[J]. J Med Chem. 2024 Jun 18:1520-4804.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2305789-66-4