Lactic acid

• Description :

  Lactic acid (DL-Lactic acid) is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactic acid is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactic acid is an oncometabolite and has immune protective role of lactate in anti-tumor immunity[1][2]. Lactic acid also has antimicrobial activity, which can be used as a food preservative[3].

• Product Name Alternative :

  DL-Lactic acid; E-270

• UNSPSC :

  12352211

• Hazard Statement :

  H315, H318

• Target :

  Bacterial; Endogenous Metabolite; Hydroxycarboxylic Acid Receptor (HCAR)

• Type :

  Natural Products

• Related Pathways :

  Anti-infection; GPCR/G Protein; Metabolic Enzyme/Protease

• Field of Research :

  Cancer; Infection; Metabolic Disease; Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/lactate.html

• Purity :

  98.00

• Solubility :

  |DMSO : ≥ 200 mg/mL

• Smiles :

  CC(O)C(O)=O

• Molecular Formula :

  C3H6O3

• Molecular Weight :

  90.08

• Precautions :

  H315, H318

• References & Citations :

  [1]Lucia Longhitano, et al. Lactate Rewrites the Metabolic Reprogramming of Uveal Melanoma Cells and Induces Quiescence Phenotype. Int J Mol Sci. 2022 Dec 20;24 (1) :24.|[2]Qiang Feng, et al. Lactate increases stemness of CD8 + T cells to augment anti-tumor immunity. Nat Commun. 2022 Sep 6;13 (1) :4981. |[3]Sallam KI. Antimicrobial and antioxidant effects of sodium acetate, sodium lactate, and sodium citrate in refrigerated sliced salmon. Food Control. 2007 May;18 (5) :566-575.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  Launched

• Isoform :

  HCAR1; Human Endogenous Metabolite

• Citation 01 :

  Adv Sci (Weinh) . 2024 May 20:e2307216.|Adv Sci (Weinh) . 2025 Jul 29:e09477.|Bioact Mater. 2024 Jun 24:40:445-459.|Biochem Biophys Res Commun. 2025 Sep 8:778:152379.|Brain Res Bull. 2025 May:224:111292.|Cancer Immunol Immunother. 2024 Oct 3;73 (12) :254.|Cell Death Differ. 2025 Sep 23.|Cell Death Dis. 2025 Feb 28;16 (1) :144.|Cell Rep. 2025 Jul 30;44 (8) :116091.|Commun Biol. 2025 Jul 8;8 (1) :1020.|Commun Biol. 2025 Nov 20;8 (1) :1626.|Ecotoxicol Environ Saf. 2025 Nov 15:307:119451.|Food Qual Saf. 2025 Aug 4.|Genes Genomics. 2025 May;47 (5) :521-531.|Int J Biol Sci. 2025 Apr 22;21 (7) :3061-3080. |J Adv Res. 2025 May 13:S2090-1232 (25) 00351-0.|J Cardiovasc Transl Res. 2025 Sep 8.|J Cell Mol Med. 2025 Jul;29 (13) :e70692.|J Cell Mol Med. 2025 Jun;29 (12) :e70669.|J Ginseng Res. 2024 May;48 (3) :298-309.|J Integr Neurosci. 2025 Feb 25;24 (2) :25949.|J Transl Med. 2025 Aug 18;23 (1) :923.|Kaohsiung J Med Sci. 2025 Nov 13:e70123.|MedComm (2020) . 2025 Aug 29;6 (9) :e70344.|Redox Biol. 2025 Apr:81:103553.|Research (Wash D C) . 2025 May 30:8:0705.|Respir Res. 2024 Nov 9;25 (1) :401.|Tissue Cell. 2024 Jul 9:89:102468.|Vet Res. 2025 Apr 30;56 (1) :94.|Adv Sci (Weinh) . 2025 Mar 27:e2413709.|Adv Sci (Weinh) . 2025 Mar 27:e2415530.|Biol Direct. 2025 May 26;20 (1) :64.|Cell Death Dis. 2025 Mar 20;16 (1) :193.|Cell Rep. 2025 Apr 9;44 (4) :115545.|Cell Res. 2023 Sep;33 (9) :679-698.|Environ Sci Technol. 2025 Aug 5;59 (30) :15705-15719.|Int Immunopharmacol. 2025 Apr 4:151:114269.|J Anim Sci Biotechnol. 2024 Jun 11;15 (1) :86.|J Exp Clin Cancer Res. 2024 Mar 5;43 (1) :68.|Phytomedicine. 2025 May:140:156628.|Stem Cell Res Ther. 2025 Oct 1;16 (1) :538.

• CAS Number :

  [50-21-5]