Loperamide (hydrochloride)

• Description:

  Loperamide (hydrochloride) (R-18553 (hydrochloride) ) is an opioid receptor agonist[1][2][3]. Loperamide hydrochloride is a selective and competitive human intestinal carboxylesterases (hiCE) inhibitor. Loperamide hydrochloride has anti-diarrheal effect[4].

• Product Name Alternative:

  R-18553 (hydrochloride)

• UNSPSC:

  12352005

• Hazard Statement:

  H301

• Target:

  Autophagy; Opioid Receptor

• Type:

  Reference compound

• Related Pathways:

  Autophagy; GPCR/G Protein; Neuronal Signaling

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease; Neurological Disease; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Loperamide-hydrochloride.html

• Concentration:

  10mM

• Purity:

  99.89

• Solubility:

  DMSO : 43.75 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 1 mg/mL (ultrasonic)

• Smiles:

  O=C(N(C)C)C(C1=CC=CC=C1)(C2=CC=CC=C2)CCN3CCC(O)(C4=CC=C(Cl)C=C4)CC3.Cl

• Molecular Formula:

  C29H34Cl2N2O2

• Molecular Weight:

  513.50

• Precautions:

  H301

• References & Citations:

  [1]Hanauer, S.B., The role of loperamide in gastrointestinal disorders. Rev Gastroenterol Disord, 2008. 8 (1) : p. 15-20.|[2]Litovitz, T., et al., Surveillance of loperamide ingestions: an analysis of 216 poison center reports. J Toxicol Clin Toxicol, 1997. 35 (1) : p. 11-9.|[3]http://www.drugs.com/mmx/loperamide-hydrochloride.html|[4]Hatfield MJ, et al. Carboxylesterase inhibitors. Expert Opin Ther Pat. 2011 Aug;21 (8) :1159-71.|[5]Svenja Zielke, et al. ATF4 links ER stress with reticulophagy in glioblastoma cells. Autophagy. 2021, 17, 9.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Citation 01:

  Cell Rep Methods. 2023 Oct 23;3 (10) :100599.|Dig Dis Sci. 2025 Nov 15.|eFood. 2025 Jul 14.|Food Qual Saf. 2024 Sep 10.|J Appl Microbiol. 2023 Aug 1;134 (8) :lxad153.|J Transl Med. 2021 Jul 23;19 (1) :317.|Viruses. 2021 Jun 28;13 (7) :1255.|Curr Med Sci. 2025 Aug 29.|Nature. 2025 Dec;648 (8094) :755-763.|Oncol Rep. 2025 Oct;54 (4) :133.|Phytomedicine. 2025 Oct 16:148:157417.

• CAS Number:

  [34552-83-5]