Loperamide (hydrochloride)

Loperamide (hydrochloride)

• CAS Number: 34552-83-5
• UNSPSC Description: Loperamide (hydrochloride) (R-18553 (hydrochloride)) is an opioid receptor agonist[1][2][3]. Loperamide hydrochloride is a selective and competitive human intestinal carboxylesterases (hiCE) inhibitor. Loperamide hydrochloride has anti-diarrheal effect[4].
• Target Antigen: Autophagy; Opioid Receptor
• Type: Reference compound
• Related Pathways: Autophagy;GPCR/G Protein;Neuronal Signaling
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Metabolic Disease; Neurological Disease; Cancer
• Assay Protocol: https://www.medchemexpress.com/Loperamide-hydrochloride.html
• Purity: 99.90
• Solubility: DMSO : 43.75 mg/mL (ultrasonic;warming;heat to 60°C)|H2O : 1 mg/mL (ultrasonic)
• Smiles: O=C(N(C)C)C(C1=CC=CC=C1)(C2=CC=CC=C2)CCN3CCC(O)(C4=CC=C(Cl)C=C4)CC3.Cl
• Molecular Weight: 513.49846
• References & Citations: [1]Hanauer, S.B., The role of loperamide in gastrointestinal disorders. Rev Gastroenterol Disord, 2008. 8(1): p. 15-20.|[2]Litovitz, T., et al., Surveillance of loperamide ingestions: an analysis of 216 poison center reports. J Toxicol Clin Toxicol, 1997. 35(1): p. 11-9.|[3]http://www.drugs.com/mmx/loperamide-hydrochloride.html|[4]Hatfield MJ, et al. Carboxylesterase inhibitors. Expert Opin Ther Pat. 2011 Aug;21(8):1159-71.|[5]Svenja Zielke, et al. ATF4 links ER stress with reticulophagy in glioblastoma cells. Autophagy. 2021, 17, 9.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
• Clinical Information: Launched