Loperamide oxide

• Description:

  Loperamide oxide (R-58425) is a orally active prodrug of the Loperamide (HY-156131) . Loperamide oxide incubation with the contents of the intestinal lumen inhibits fluid secretion under aerobic conditions[1][2].

• Product Name Alternative:

  R-58425

• UNSPSC:

  12352005

• Hazard Statement:

  H301

• Target:

  Others

• Type:

  Reference compound

• Related Pathways:

  Others

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/loperamide-oxide.html

• Smiles:

  O=C(C(C1=CC=CC=C1)(CC[N@+]2(CC[C@](C3=CC=C(C=C3)Cl)(CC2)O)[O-])C4=CC=CC=C4)N(C)C

• Molecular Formula:

  C29H33ClN2O3

• Molecular Weight:

  493.04

• Precautions:

  P264-P270-P330-P405-P501

• References & Citations:

  [1]Hardcastle J, et al. The effect of loperamide oxide on prostaglandin-stimulated fluid transport in rat small intestine. J Pharm Pharmacol. 1990;42 (5) :364-366. |[2]Kamali F, Huang ML. Increased systemic availability of loperamide after oral administration of loperamide and loperamide oxide with cotrimoxazole. Br J Clin Pharmacol. 1996;41 (2) :125-128.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [106900-12-3]