Loperamide

• Description:

  Loperamide (ADL 2-1294) is a selective μ opioid receptor agonist with Kis of 3, 48 and 1156 nM against μ, δ and κ opioid receptor, respectively. Loperamide can be used as an antidiarrheal agent[1].

• Product Name Alternative:

  ADL 2-1294

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319, H320

• Target:

  Opioid Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/loperamide.html

• Purity:

  99.85

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C(C(C1=CC=CC=C1)(CCN2CCC(C3=CC=C(C=C3)Cl)(CC2)O)C4=CC=CC=C4)N(C)C

• Molecular Formula:

  C29H33ClN2O2

• Molecular Weight:

  477.04

• Precautions:

  H315, H319, H320

• References & Citations:

  [1]DeHaven-Hudkins DL, et al. Loperamide (ADL 2-1294), an opioid antihyperalgesic agent with peripheral selectivity. J Pharmacol Exp Ther. 1999 Apr;289 (1) :494-502.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Citation 01:

  Curr Med Sci. 2025 Aug 29.|Nature. 2025 Dec;648 (8094) :755-763.|Oncol Rep. 2025 Oct;54 (4) :133.|Phytomedicine. 2025 Oct 16:148:157417.|Cell Rep Methods. 2023 Oct 23;3 (10) :100599.|Dig Dis Sci. 2025 Nov 15.|eFood. 2025 Jul 14.|Food Qual Saf. 2024 Sep 10.|J Appl Microbiol. 2023 Aug 1;134 (8) :lxad153.|J Transl Med. 2021 Jul 23;19 (1) :317.|Viruses. 2021 Jun 28;13 (7) :1255.

• CAS Number:

  [53179-11-6]