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BAY-958

CAT: 0804-HY-121081Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-121081Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BAY-958 is a potent PTEFb/CDK9 inhibitor with high selectivity demonstrated, particularly within the CDK family. BAY-958 shows strong antiproliferative activity against cancer cell lines such as HeLa and MOLM-13. BAY-958 exhibits good metabolic stability. BAY-958 effectively inhibits tumor growth in mouse xenograft models without significant toxicity[1].
CAS Number
1335490-39-5
UNSPSC
12352005
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bay-958.html
Smiles
O=S(CC1=CC=CC(NC2=NC(C3=CC=C(F)C=C3OC)=NC=N2)=C1)(N)=O
Molecular Formula
C17H16FN5O3S
Molecular Weight
389.40
References & Citations
[1]Identification of atuveciclib (BAY 1143572), the first highly selective, clinical PTEFb/CDK9 inhibitor for the treatment of cancer
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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