BAY-826

• Description:

  BAY-826, a chemical probe, is a selective and potent TIE-2 inhibitor with a Kd of 1.6 nM, respectively.

• UNSPSC:

  12352005

• Target:

  Discoidin Domain Receptor; Tie

• Type:

  Reference compound

• Related Pathways:

  Protein Tyrosine Kinase/RTK

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/BAY-826.html

• Purity:

  99.94

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C(NC1=C(C)C=C(C)C(N2C3=CC(C4=CN=CC=C4)=NN3C=C2)=C1)C5=CC(C#N)=CC(S(F)(F)(F)(F)F)=C5

• Molecular Formula:

  C26H19F5N6OS

• Molecular Weight:

  558.53

• References & Citations:

  [1]Schneider H, et al. J Neurochem. 2017 Jan; 140 (1) :170-182. doi: 10.1111/jnc.13877. Epub 2016 Dec 12.Novel TIE-2 inhibitor BAY-826 displays in vivo efficacy in experimental syngeneic murine glioma models.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Tie2

• CAS Number:

  [1448316-08-2]