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MC-1-F2

CAT: 0804-HY-149894-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-149894-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MC-1-F2 is a FOXC2 inhibitor. MC-1-F2 shows a binding affinity (Kd) of 26 μM for full-length FOXC2. MC-1-F2 reduces epithelial-mesenchymal transition (EMT) markers in breast cancer cells, suppresses cancer stem cell (CSC) properties and reduces invasiveness in castration-resistant prostate cancer (CRPC) cells. MC-1-F2 can be used for the study of CRPC and breast cancer[1][2].
CAS Number
2376894-10-7
UNSPSC
12352005
Target
Cadherin; c-Myc
Type
Reference compound
Related Pathways
Apoptosis; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mc-1-f2.html
Purity
99.78
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
N=C(NCCCCNC1=NC(NC2=CC=C(C=C2)OC3=CC=CC=C3)=NC(N4CCN(CC4)C5=NC(NC6=CC=C(N7CCOCC7)C=C6)=NC(N)=N5)=N1)N
Molecular Formula
C37H46N16O2
Molecular Weight
746.87
References & Citations
[1]Castaneda M, et al. A FOXC2 inhibitor, MC-1-F2, as a therapeutic candidate for targeting EMT in castration-resistant prostate cancer. Bioorg Med Chem Lett. 2023 Jul 15;91:129369. |[2]Castaneda M, et al. A Forkhead Box Protein C2 Inhibitor: Targeting Epithelial-Mesenchymal Transition and Cancer Metastasis. Chembiochem. 2018 Jul 4;19 (13) :1359-1364.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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