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5-Iodotubercidin

CAT: 0804-HY-15424-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15424-01Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
5-Iodotubercidin (NSC 113939), an ATP mimetic, is a potent adenosine kinase inhibitor with an IC50 of 26 nM. 5-Iodotubercidin (NSC 113939) initiates glycogen synthesis in isolated hepatocytes by causing inactivation of phosphorylase and activation of glycogen synthase. 5-Iodotubercidin (NSC 113939) also inhibits CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2, PKC and Haspin[1][2][3].
CAS Number
24386-93-4
Product Name Alternative
NSC 113939; 5-ITu
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Adenosine Kinase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/5-Iodotubercidin.html
Purity
99.80
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
NC1=C2C(N([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)C=C2I)=NC=N1
Molecular Formula
C11H13IN4O4
Molecular Weight
392.15
Precautions
H302, H315, H319, H335
References & Citations
[1]Massillon D, et al. Identification of the glycogenic compound 5-iodotubercidin as a general protein kinase inhibitor. Biochem J. 1994 Apr 1;299 (Pt 1) :123-8.|[2]Ugarkar BG, et al. Adenosine kinase inhibitors. 1. Synthesis, enzyme inhibition, and antiseizure activity of 5-iodotubercidin analogues. J Med Chem. 2000 Jul 27;43 (15) :2883-93.|[3]García-Villafranca J, et al. Effects of 5-iodotubercidin on hepatic fatty acid metabolism mediated by the inhibition of acetyl-CoA carboxylase. Biochem Pharmacol. 2002 Jun 1;63 (11) :1997-2000.|[4]De Antoni A, et al. A small-molecule inhibitor of Haspin alters the kinetochore functions of Aurora B. J Cell Biol. 2012 Oct 15;199 (2) :269-84.|[5]Acharya MM, et al. Adenosine Kinase Inhibition Protects against Cranial Radiation-Induced Cognitive Dysfunction. Front Mol Neurosci. 2016 Jun 3;9:42.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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